In the electric power industry, our company according to oxygen-enriched combustion on the characteristics of the requirements, based on the type and process of air separation and oxygen production equipment, the design and development of an improved air separating flow and parameter selection suitable for the oxygen-enriched combustion generator set, based on the thermodynamics principle of air seperation and the calculation method of the main equipment consumption of the system, 300MW coal-fired oxygen-enriched combustion unit as object, design different air separation process, different oxygen purity of air separation equipment, and the current industrial use of high purity air separation plant actual power consumption comparison, plant electricity consumption rate can be reduced by about 13%.